Neuroimaging Software for functional MRI


nordicBrainEx is a comprehensive neuroimaging software for functional MRI specifically designed for the clinical workflow. Simple and user-friendly interface improves user productivity, while the automated protocols, processing steps, and quality control features minimize the probability of error or variability in the quality of the results.

Advanced volume of interest tools, combined with 2D/3D visualization of BOLD activation areas, DTI tractography, and MRI perfusion and permeability imaging (DSC and DCE) allow clinicians to perform extensive evaluations of normal and pathological brain tissue. It is possible to use all four modules in one application or choose a specific module of interest.

nordicBrainEx is DICOM compatible and capable of analyzing data from all major MRI vendors. All processed data can be saved in a comprehensive report, sent to PACS, or exported to neuronavigation systems.


Selected key features:

·       User-friendly interface, optimized workflow and fast analysis.

·       Module-based post-processing and analysis of Perfusion, DCE, DTI and BOLD fMRI based on DICOM MR input data.

·       Robust co-registration of functional (BOLD, DTI, DSC, DCE) with structural MR images.

·       Easy communication with PACS and other remote entities for retrieving data for analysis and for sending results.

·       Unlimited combination of overlays and underlays - combine BOLD fMRI, DTI, DSC perfusion and DCE overlays in same view, with flexible visualization and analysis options.

·       Saving of parametric maps, 3D snapshots or animations to various file formats or directly to PACS.

·       Export results to a neuronavigation system.

·       Runs on standard Windows platform, no special hardware required.


BOLD fMRI module

BOLD fMRI is used to highlight small magnetic susceptibility changes in the human brain in areas with altered blood-flow resulting from neuronal activity. The BOLD fMRI analysis module can be used to generate and visualize activation maps from acquired BOLD fMRI time series, using a general linear model. Preprocessing includes co-registration of BOLD images with structural MR images, motion correction, slice-time correction, Gaussian smoothing and high-pass temporal filtering. In the BOLD fMRI module, several conditions can be displayed in the same view, both in 2D and 3D, and the BOLD threshold can be adjusted interactively. VOI-tools can be used to inspect the time-intensity curves for quality assessment. Results can be exported for neuronavigation or saved to PACS.

DTI module

Diffusion analysis is used to visualize local water diffusion properties from the analysis of diffusion-weighted MRI data. Fiber tracking utilizes the directional dependency of diffusion to statistically model the white matter structure in the brain. In the DTI module, diffusion data with at least 6 directions can be used to calculate the diffusion tensor and produce diffusion output parameter maps such as ADC (mean diffusivity), FA (fractional anisotropy), Trace, eigenvalue maps etc. Pre-processing includes co-registration of DT images with structural MR images, and motion and Eddy current corrections. Diffusion gradient information can be automatically extracted from the DICOM header or specified manually. DTI tractography is automatically displayed in 3D view, and multiple volumes/regions of interest can be used to define selected fiber groups and explore connectivity. Fiber groups can be presented in 2D/3D and exported to neuronavigation or saved to PACS.  

Perfusion module

Dynamic susceptibility contrast imaging (perfusion MRI) is based on the analysis of tissue signal change following a bolus injection of a Gadolinium-based contrast agent, providing information about blood vessel structures and characteristics. The perfusion analysis includes co-registration of DSC images with structural MR images, normalization, leakage correction and vessel removal. The analysis is fast and generates cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time-to-peak (TTP), leakage and vessel mask output maps. Tissue response curves can be viewed from any region in the perfusion maps, together with histogram information.

DCE module

Dynamic contrast enhanced imaging (DCE-MRI) is based on the analysis of tissue signal change following a bolus injection of a Gadolinium-based contrast agent, enabling analysis of tissue permeability parameters, thus providing information about vascular permeability and intra- and extravascular volume. The DCE analysis employs two compartment modelling to generate output maps such as area under the curve (AUC), volume transfer constant (Ktrans), rate constant (Kep), plasma volume (Vp), fractional volume (Ve) and time to peak (TTP).

The MPR viewer displays perfusion and permeability maps, fiber tracking, and BOLD fMRI data together for extensive patient evaluation.



Ultra fast analysis

Real-time fMRI analysis in less than 15 seconds!


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